منابع مشابه
Antihypertensive efficacy of aliskiren: is hydrochlorothiazide an appropriate benchmark?
The thorough prospective, randomized, double-blind trial of Schmieder et al1 in the current issue of Circulation convincingly documents that aliskiren treatment provided significantly greater blood pressure (BP) reduction than hydrochlorothiazide. The study is well done; the number of patients (n 1124) is impressive; and the efficacy variables were analyzed, as is appropriate for an intention-t...
متن کاملRenin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy
Hypertension is a major risk factor for the development of cardiovascular and renal disease. The incidence of hypertension is increasing globally and the rate of blood pressure control remains inadequate. Renin-angiotensin-aldosterone system (RAAS) plays a crucial role in volume regulation and maintenance of blood pressure. Pathological activation of RAAS results in chronic hypertension and con...
متن کاملAntihypertensive Therapy
Effective antihypertonsive drug therapy began with the ganglion-blocking agents, followed by reserpine and hydralarine. later advances included the benzothiadiazine saluretic agents and more recently compounds which specifically inhibit the sympathetic nervous system, such as guanethidine, alpha-methyldopa, and certain amine oxidase inhibitors. Among the antihypertensive drugs, molecular modifi...
متن کاملLong-term antihypertensive therapy with captopril.
Most forms of hypertension require life-long treatment; thus, it is important to determine the continuing effectiveness and safety of any new therapeutic agent. While participating in various investigational studies, 7103 hypertensive patients received captopril, of whom 4397 were treated for 3 months to 4 years. The 4-year patients included 2498 with mild or moderate essential hypertension (di...
متن کاملContemporary antihypertensive therapy.
Pharmacotherapy of human hypertension is effective, safe and well-tolerated. Antihypertensive drugs are of three broad classes: diuretics, sympatholytics and vasodilators. The use of each class is discussed and a summary of therapeutic considerations offered for representative agents. Recent trends in antihypertensive therapy are identified.
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ژورنال
عنوان ژورنال: Kidney International
سال: 2008
ISSN: 0085-2538
DOI: 10.1038/sj.ki.5002732